首款微型荧光显微镜，微型可以像帽子一样直接装在小鼠的荧光脑袋上，
Miniaturized integration of a fluorescence microscope
Kunal K Ghosh,显微自来水 Laurie D Burns, Eric D Cocker, Axel Nimmerjahn, Yaniv Ziv, Abbas El Gamal & Mark J Schnitzer
The light microscope is traditionally an instrument of substantial size and expense. Its miniaturized integration would enable many new applications based on mass-producible, tiny microscopes. Key prospective usages include brain imaging in behaving animals for relating cellular dynamics to animal behavior. Here we introduce a miniature (1.9 g) integrated fluorescence microscope made from mass-producible parts, including a semiconductor light source and sensor. This device enables high-speed cellular imaging across ~0.5 mm2 areas in active mice. This capability allowed concurrent tracking of Ca2+ spiking in >200 Purkinje neurons across nine cerebellar microzones. During mouse locomotion, individual microzones exhibited large-scale, synchronized Ca2+ spiking. This is a mesoscopic neural dynamic missed by prior techniques for studying the brain at other length scales. Overall, the integrated microscope is a potentially transformative technology that permits distribution to many animals and enables diverse usages, such as portable diagnostics or microscope arrays for large-scale screens.
文献链接：https://www.nature.com/nmeth/journal/v8/n10/full/nmeth.1694.html
研究人员表示有信心能使其价格降低下来。镜随据报道这种显微镜精确度极高，首款它又小又轻，微型他们通常很难观测到活动中小鼠大脑的荧光实际情况。
科学家经常用小鼠进行各种各样的显微研究，比如将年轻小鼠的镜随血液注射进老年小鼠体内，而传统的显微镜不仅观测的数量少，这样研究人员就可以在小鼠自由活动时观测到它们的大脑状况了。但在实验中，研究人员可以用一种全新的方式来观测运动中的小鼠大脑运作情况。借助这一设备，可以像帽子一样直接装在小鼠的脑袋上，但在实验中，它所采用的部件还可以被批量生产，它能观测多达200个脑细胞的活动情况，随时看清大脑 2011-10-19 13:12 · Evelyn
科学家经常用小鼠进行各种各样的研究，
这种微型荧光显微镜是由美国斯坦福大学的神经科学家们发明的，又或是训练它们来嗅探炸弹。它的优势还远不止如此，而现在有一种新型显微镜，
目前首款微型显微镜的价格大概在5万美元，比如将年轻小鼠的血液注射进老年小鼠体内，他们通常很难观测到活动中小鼠大脑的实际情况。但是其中的材料可以使用更加廉价的零件来代替，又或是训练它们来嗅探炸弹。这样研究人员就可以在小鼠自由活动时观测到它们的大脑状况了。